Extracolonic Manifestations of Hereditary Colorectal Cancer Syndromes
نویسندگان
چکیده
منابع مشابه
Gynecologic Manifestations of Hereditary Nonpolyposis Colorectal Cancer
Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant cancer susceptibility syndrome associated with inherited defects in the DNA mismatch repair system. HNPCC family members are at high risk for developing colorectal, endometrial, and ovarian cancers. Studies of HNPCC families have helped define the important role that mismatch repair genes play in the molecular pathogenes...
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In their article, Taylor and Mutch bring attention to the gynecologic cancer risks associated with hereditary nonpolyposis colorectal cancer (HNPCC).[1] The identification of individuals and families at risk for HNPCC has often focused on the colon cancer phenotype, but the diagnosis of endometrial or ovarian cancer should also be considered. Lu and colleagues conducted a study of 101 women wit...
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Colorectal cancer (CRC) is one of the most important causes of death in the world. Hereditary CRC is found in 5-10% of CRC patients. In this review, we will focus on the major forms of hereditary CRC and their management according to the most recent literature available.
متن کاملRecognition and management of hereditary colorectal cancer syndromes.
Over 1,900 colorectal tumors will arise in association with a hereditary colorectal cancer syndrome in Spain in 2009. The genetic defects responsible for the most common syndromes have been discovered in recent years. Genetic testing helps diagnose affected individuals and allows identification of individuals at-risk. Colonoscopy and prophylactic colectomy decrease colorectal cancer incidence a...
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Hereditary factors are thought to play a role in at least one third of patients with colorectal cancer (CRC) but only a limited proportion of these have mutations in known high-penetrant genes. In a relatively large part of patients with a few or multiple colorectal polyps the underlying genetic cause of the disease is still unknown. Using exome sequencing in combination with linkage analyses t...
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ژورنال
عنوان ژورنال: Clinics in Colon and Rectal Surgery
سال: 2008
ISSN: 1531-0043,1530-9681
DOI: 10.1055/s-0028-1089941